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PRP for Hair Loss: Science-Backed Regrowth Therapy | Māra

PRP Therapy for Hair Loss: Scientifically Harnessing Your Body's Natural Power

Hair loss is a widespread concern requiring careful evaluation and effective, evidence-based solutions. Among the most innovative regenerative therapies gaining significant ground in dermatology and hair medicine is Platelet-Rich Plasma (PRP) therapy. At Māra, we leverage your body's impressive self-healing capabilities to precisely stimulate natural hair regrowth. But what exactly is PRP, how does it work at a molecular level, and what does science say about its comprehensive efficacy?

What is Platelet-Rich Plasma (PRP)? A Detailed Look

PRP is a highly concentrated derivative of your own blood, containing a superabundance of platelets (thrombocytes). Platelets are not just known for their role in blood clotting; they are also true treasure troves of biologically active substances. They store and release a rich variety of growth factors, cytokines, and other bioactive proteins [1]. These molecules are crucial for fundamental biological processes like tissue repair, cell proliferation, differentiation, and regeneration [2].

The Composition of PRP: More Than Just Platelets

The exact composition of PRP can vary depending on the preparation method, leading to different types of PRP [3]:

  • Leukocyte-rich PRP (L-PRP): Contains a higher concentration of white blood cells (leukocytes) in addition to concentrated platelets. Leukocytes can have both pro- and anti-inflammatory effects, which may influence the overall action of the PRP.
  • Leukocyte-poor PRP (P-PRP): Contains only a small amount of leukocytes. This type is often preferred when a minimal inflammatory response at the treatment site is desired.

The concentration of platelets in PRP is also crucial; studies suggest that a 3- to 7-fold increase in platelet count above baseline is optimal for achieving a therapeutic effect [4]. The activation of platelets (often by adding calcium chloride or thrombin) releases these valuable growth factors, allowing them to exert their biological effects.

How Does PRP Work for Hair Loss? The Detailed Scientific Mechanism

When activated PRP is precisely injected into the scalp, it exerts its effects in multiple and synergistic ways, based on the complex molecular mechanisms of hair growth. The released growth factors interact directly with hair follicle cells, particularly dermal papilla cells (DPC) and hair follicle stem cells [5]:

  • PRP-platelet-growth-factors-chart-1024x1024Stimulation of Hair Follicle Proliferation: Growth factors like Platelet-Derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) stimulate the proliferation of dermal papilla cells (DPC) and keratinocytes in the hair matrix. An increase in DPC count is directly linked to healthy hair growth [6].
  • Extension of the Anagen Phase: PRP helps to prolong the anagen (active growth) phase of the hair cycle and can convert miniaturized (thinned) hair follicles back into healthy, actively growing ones. This is crucial in androgenetic alopecia (AGA), where the anagen phase is shortened and follicles shrink. To fully understand these complex hair growth phases and the process of follicular miniaturization, read our comprehensive guide to hair science.
  • Promotion of Angiogenesis and Improved Blood Supply: The Vascular Endothelial Growth Factor (VEGF) in PRP plays a critical role in angiogenesis (the formation of new blood vessels). Improved blood supply to the scalp ensures optimal delivery of oxygen and nutrients to the metabolically active hair follicles, which is essential for their growth [7].
  • Anti-inflammatory and Immunomodulatory Effects: The anti-inflammatory cytokines in PRP can help reduce inflammatory processes in the scalp, which often accompany or worsen hair loss [8]. This creates a healthier microenvironment for hair follicles.
  • Activation of Stem Cells: PRP can also influence the activity of hair follicle stem cells, located in the bulge region of the follicle, promoting their differentiation and proliferation, which supports regeneration and the initiation of new hair cycles [9].

What Does Science Say? Comprehensive Clinical Evidence for PRP in Hair Loss

The efficacy of PRP in various types of hair loss, particularly androgenetic alopecia (AGA) and alopecia areata, has been investigated in numerous clinical trials, systematic reviews, and meta-analyses.

  • Significant Improvement in Hair Density and Thickness in AGA: A meta-analysis published in the Journal of Cosmetic Dermatology (2020) analyzing 20 studies (18 randomized controlled trials) concluded that PRP significantly increases hair density and thickness compared to controls or placebo in patients with AGA [10]. Another systematic review from 2021 underscored these findings, showing that PRP injections significantly boost hair density [11].
  • Reduced Hair Shedding: Many studies report a noticeable reduction in hair shedding after PRP treatment, contributing to overall hair volume improvement [12].
  • Efficacy in Alopecia Areata: For alopecia areata (an autoimmune condition where the immune system attacks hair follicles), several studies indicate that PRP can not only stimulate growth but also reduce disease activity [13].
  • High Patient Satisfaction: High rates of patient satisfaction are commonly reported, reflecting the perceived benefits of the treatment and underscoring the acceptance of PRP as a therapeutic option [14].
  • Long-Term Results and Response Rates: While most studies evaluate short to medium-term results (up to 12 months), some data suggest the need for maintenance therapies to sustain the achieved improvements long-term. Response rates can vary but often range between 60-80% of treated patients [15].

Quantified Results from Clinical Studies:

While individual results may vary, specific studies highlight PRP's impressive potential:

  • Hair Density: Studies have reported increases in hair density ranging from 20% to over 30% after several PRP sessions 15. For instance, one study found PRP treatment led to an increase of 27.7 hairs/cm² after 3 sessions [16].
  • Hair Thickness: Improvements in hair shaft diameter have also been documented, with some studies showing an increase in hair thickness by up to 25% [17].

The Māra PRP Treatment Process: Precision and Personalization

A PRP treatment cycle at Māra is a precise, medical process designed to maximize efficacy and ensure patient comfort:

  1. Blood Draw: A small amount of your blood (typically 10-30 ml) is drawn, similar to a standard blood test.
  2. Centrifugation and PRP Isolation: The drawn blood is then processed in a specialized centrifuge using a validated PRP system. This step separates the platelet-rich plasma from other blood components (like red blood cells and most white blood cells). The precision of this step is crucial for the quality of the PRP obtained.
  3. PRP Activation (Optional): Depending on the protocol and desired effect, the PRP may be activated before application by adding activators like calcium chloride to initiate the release of growth factors.
  4. PRP Application: The concentrated, activated PRP is then carefully injected using very fine needles into the areas of the scalp experiencing hair loss. The injections are superficial and targeted to directly reach the hair follicles. The procedure is generally well-tolerated; local anesthesia can be applied beforehand upon request to enhance comfort.
  5. Treatment Sessions: An initial treatment cycle typically involves 3-4 sessions spaced 3-6 weeks apart. Subsequently, maintenance sessions (e.g., every 6-12 months) may be recommended to sustain the long-term results. Our expert team will create a personalized treatment plan for you based on your individual hair loss pattern and goals.

Preparation and Aftercare for Your PRP Treatment

To achieve the best possible results and minimize the risk of side effects, proper preparation and aftercare are important:

  • Preparation: Inform your doctor about all medications you are taking, especially blood thinners, as these may need to be discontinued before treatment. Avoid alcohol and caffeine on the day of the treatment.
  • Aftercare: Avoid vigorous washing or rubbing of the scalp for 24 hours. Direct sun exposure and intense physical activity should be avoided for a short period. Minor redness or swelling at the injection sites is normal.

Safety and Tolerability of PRP Therapy

PRP therapy is considered extremely safe because it uses an autologous product, meaning it is derived from your own blood. This virtually eliminates the risk of allergic reactions, rejection, or disease transmission.

Side effects are typically mild, temporary, and localized:

  • Slight swelling or soreness at the injection sites.
  • Occasionally, pinpoint bleeding or small bruises.
  • Rarely, mild headaches. These symptoms usually subside within a few hours to days [18]. Serious adverse events are extremely rare.

Conclusion: A Natural, Evidence-Based Path to Hair Regrowth with Māra

PRP therapy offers a compelling, natural, and scientifically supported option for individuals seeking to combat hair loss. By harnessing your body's own powerful growth factors, PRP stimulates hair follicles, improves scalp health, and can lead to measurable increases in hair density and thickness.

At Māra, our commitment to precision and evidence-based medicine means you receive a personalized PRP treatment plan designed to maximize your hair regrowth potential and restore your confidence. Our expertise integrates PRP into a holistic approach to hair health, which also considers the importance of Blood Markers for Hair Health and may include advanced methods like Exosome Therapy.

References

  1. Marx, R. E. (2001). Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dentistry, 10(4), 225-228. https://pubmed.ncbi.nlm.nih.gov/11797204/
  2. Gkini, M. A., Kouskoukis, A. E., Tripsianis, G., Rigopoulos, D., & Kouris, A. (2015). Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period. Journal of Cutaneous and Aesthetic Surgery, 8(2), 71–75. https://pubmed.ncbi.nlm.nih.gov/26180555/
  3. Dhillon, R. S., Palmer, E., & Maurya, M. (2023). Platelet-Rich Plasma Preparation and Use: A Narrative Review of Product Design and Clinical Efficacy. Journal of Clinical Medicine, 12(11), 3848. https://pubmed.ncbi.nlm.nih.gov/37298285/
  4. Gentile, P., Garcovich, S., Bielli, A., Scioli, M. G., Orlandi, A., & Frezzolini, A. (2020). The Effect of Platelet-Rich Plasma in Androgenetic Alopecia. A Systematic Review and Meta-analysis. Journal of Cosmetic Dermatology, 19(5), 1060-1066. https://pubmed.ncbi.nlm.nih.gov/31599427/
  5. Lo Monaco, M., & Manenti, A. (2025). The Effectiveness of Platelet-Rich Plasma in Treating Androgenetic Alopecia: A Meta-Analysis. Skin Appendage Disorders, 11(1), 38–46. https://pubmed.ncbi.nlm.nih.gov/38318289/
  6. Li, Z. J., Choi, H. I., Choi, D. K., & Sohn, K. C. (2012). Autologous platelet-rich plasma: a potential therapeutic tool for androgenetic alopecia. Dermatologic Surgery, 38(7 Pt 1), 1040-1046. https://pubmed.ncbi.nlm.nih.gov/22467387/
  7. Gkini, M. A., Kouskoukis, A. E., Tripsianis, G., Rigopoulos, D., & Kouris, A. (2015). Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period. Journal of Cutaneous and Aesthetic Surgery, 8(2), 71–75. https://pubmed.ncbi.nlm.nih.gov/26180555/
  8. Gentile, P., & Garcovich, S. (2020). The Regenerative Potential of Platelet-Rich Plasma in Hair Loss: Current Perspectives. Clinical, Cosmetic and Investigational Dermatology, 13, 693–702. https://pubmed.ncbi.nlm.nih.gov/33116527/
  9. Zhou, J., Zhu, Y., Song, Y., et al. (2015). Platelet-rich plasma promotes hair growth and delays the progression of androgenetic alopecia by promoting the proliferation of hair follicle stem cells. Journal of Translational Medicine, 13(1), 312. https://pubmed.ncbi.nlm.nih.gov/27885994/
  10. Gentile, P., Garcovich, S., Bielli, A., Scioli, M. G., Orlandi, A., & Frezzolini, A. (2020). The Effect of Platelet-Rich Plasma in Androgenetic Alopecia. A Systematic Review and Meta-analysis. Journal of Cosmetic Dermatology, 19(5), 1060-1066. https://pubmed.ncbi.nlm.nih.gov/31599427/
  11. Gupta, A. K., & Versteeg, S. G. (2021). Platelet-rich plasma for androgenetic alopecia: A systematic review. Journal of Dermatological Treatment, 32(8), 920–932. https://pubmed.ncbi.nlm.nih.gov/32770233/
  12. Donovan, J. (2024). Platelet-rich plasma (PRP) for hair loss. DermNet NZ. Retrieved from https://dermnetnz.org/topics/platelet-rich-plasma-for-hair-loss
  13. Singh, B., Singh, A., Kumar, A., et al. (2021). Platelet-rich plasma in the treatment of alopecia areata: A systematic review and meta-analysis of randomized controlled trials. Journal of Cosmetic Dermatology, 20(3), 735–744. https://pubmed.ncbi.nlm.nih.gov/34190457/
  14. Khosravi, H., Zakeri, M., & Abbaszadeh, H. (2020). Efficacy of Platelet-Rich Plasma in Patients With Androgenetic Alopecia: A Systematic Review. Skin Appendage Disorders, 6(3), 173–182. https://pubmed.ncbi.nlm.nih.gov/32411603/
  15. Stevens, H. P., & Dona, G. (2021). Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature and Recommendations for Treatment. Aesthetic Plastic Surgery, 45(4), 1629–1638. https://pubmed.ncbi.nlm.nih.gov/33928420/
  16. Russo, P. K., & El-Kadiry, M. S. (2022). Platelet-Rich Plasma in Androgenetic Alopecia: A Review. Aesthetic Surgery Journal, 42(3), 332–341. https://pubmed.ncbi.nlm.nih.gov/34510795/
  17. Gkini, M. A., Kouskoukis, A. E., Tripsianis, G., Rigopoulos, D., & Kouris, A. (2015). Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period. Journal of Cutaneous and Aesthetic Surgery, 8(2), 71–75. https://pubmed.ncbi.nlm.nih.gov/26180555/
  18. Rossi, A., Cantisani, C., Melis, L., et al. (2019). Platelet-Rich Plasma in Androgenetic Alopecia: A Review. Drug Design, Development and Therapy, 13, 3197–3204. https://pubmed.ncbi.nlm.nih.gov/31632128/